Hornblende, a calcium-rich amphibole, is a key component of both the lower crust and a metamorphosed subducting oceanic crust. However, unlike other minerals, amphibole deformation mainly occurs through a combination of plastic and brittle mechanisms without a distinct transition to crystal plasticity, which makes amphibole's rheology complex and hard to characterize. I will present a combination of two experimental tools of hornblende deformation that span from millimeters to nanometer scales and encompass different deformation mechanism regimes. The first set of deformation experiments was done using a solid-medium Griggs apparatus under pressure of 1 GPa, 400, 600, and 800°C, and natural hornblendite samples with strong initial texture. Post-mortem analysis of the pre-textured samples reveals asymmetrical deformation manifested in kink bands. Importantly, although fractures are observed at all temperatures, deformation is accommodated via dislocations (i.e., plasticity), illustrating an interesting interplay between the nucleation of fractures and dislocation walls at higher temperatures. The second set of deformation tests investigates the local mechanical properties of the grain through nanoindentation tests, revealing the anisotropy of hornblende grains and the elastic-plastic response of the mineral locally below the hard indenter. Nanoindentation tests demonstrate hornblende's strong elastic anisotropy properties and temperature-dependent plastic deformation (hardness). Combining these two experimental approaches illustrates the critical role of amphibole elastic properties in its mechanical properties. It will be discussed in light of hornblende plasticity's role in the lower crust.